![]() Reported positive effects extend beyond PTSD symptoms only. Classical psychedelics (such as psilocybin and LSD) induce psychoactive effects (on behavior or experience) that could contribute to the psychotherapeutic treatment of PTSD but have not yet been investigated in controlled studies. Current studies are investigating whether the use of ketamine in combination with psychotherapy can lead to lasting reductions in PTSD symptoms. Based on a small number of studies, ketamine administration appears to lead to temporary symptom relief. RESULTS: MDMA-assisted psychotherapy has shown to produce lasting reductions in PTSD symptoms in multiple RCTs. ![]() METHOD: A scoping review of the available literature. AIM: An overview of the current evidence, therapeutic context, and possible mechanisms of action of different types of psychedelics in the treatment of PTSD. Psychedelics offer new treatment opportunities. Posttraumatic stress disorder (PTSD) is often a chronic condition, despite the availability of various evidence-based treatment options.
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